Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants

Redox imbalance has been implicated in the pathogenesis of many acute and chronic lung diseases. The b-Zip transcription factor Nrf2 acts via an antioxidant/electrophilic response element to regulate antioxidants and maintain cellular redox homeostasis. Our previous studies have shown that Nrf2-defi...

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Autors principals: Reddy, Narsa M., Kleeberger, Steven R., Cho, Hye-Youn, Yamamoto, Masayuki, Kensler, Thomas W., Biswal, Shyam, Reddy, Sekhar P.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2007
Matèries:
Rapid Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899352/
https://ncbi.nlm.nih.gov/pubmed/17413030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0004RC
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