Prostacyclin Analogs Inhibit Fibroblast Contraction of Collagen Gels through the cAMP-PKA Pathway

Prostacyclin is an arachidonic acid metabolite that modulates vascular tone within the lung. The current study evaluated the hypothesis that prostacyclin can also modulate tissue remodeling by affecting fibroblast-mediated contraction of extracellular matrix. To accomplish this, fibroblasts were cul...

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Detalhes bibliográficos
Main Authors: Kamio, Koichiro, Liu, Xiangde, Sugiura, Hisatoshi, Togo, Shinsaku, Kobayashi, Tetsu, Kawasaki, Shinsaku, Wang, Xingqi, Mao, Lijun, Ahn, Youngsoo, Hogaboam, Cory, Toews, Myron L., Rennard, Stephen I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899347/
https://ncbi.nlm.nih.gov/pubmed/17363776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0009OC
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