Prostacyclin Analogs Inhibit Fibroblast Contraction of Collagen Gels through the cAMP-PKA Pathway

Prostacyclin is an arachidonic acid metabolite that modulates vascular tone within the lung. The current study evaluated the hypothesis that prostacyclin can also modulate tissue remodeling by affecting fibroblast-mediated contraction of extracellular matrix. To accomplish this, fibroblasts were cul...

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Bibliographic Details
Main Authors: Kamio, Koichiro, Liu, Xiangde, Sugiura, Hisatoshi, Togo, Shinsaku, Kobayashi, Tetsu, Kawasaki, Shinsaku, Wang, Xingqi, Mao, Lijun, Ahn, Youngsoo, Hogaboam, Cory, Toews, Myron L., Rennard, Stephen I.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899347/
https://ncbi.nlm.nih.gov/pubmed/17363776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0009OC
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