Cigarette Smoke Stimulates Matrix Metalloproteinase-2 Activity via EGR-1 in Human Lung Fibroblasts

Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Recent reports of increased matrix metalloproteinase-2 (MMP-2) in lungs of patients with emphysema support the paradigm of proteinase/antiproteinase imbalance in the pathogenesis of COPD. We sought to define t...

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Bibliographic Details
Main Authors: Ning, Wen, Dong, Yingying, Sun, Jingxia, Li, Chaojun, Matthay, Michael A., Feghali-Bostwick, Carol A., Choi, Augustine M. K.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899323/
https://ncbi.nlm.nih.gov/pubmed/17099140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0106OC
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