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Epithelial Organic Cation Transporters Ensure pH-Dependent Drug Absorption in the Airway
Most inhaled β(2)-adrenergic agonist and anticholinergic bronchodilators have low lipid solubility because of their transient or permanent positive net charge at physiologic pH. Airway absorption of these cationic drugs is incompletely understood. We examined carrier-mediated mechanisms of cationic...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Thoracic Society
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899308/ https://ncbi.nlm.nih.gov/pubmed/16917073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0230OC |
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