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Epithelial Organic Cation Transporters Ensure pH-Dependent Drug Absorption in the Airway
Most inhaled β(2)-adrenergic agonist and anticholinergic bronchodilators have low lipid solubility because of their transient or permanent positive net charge at physiologic pH. Airway absorption of these cationic drugs is incompletely understood. We examined carrier-mediated mechanisms of cationic...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Thoracic Society
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899308/ https://ncbi.nlm.nih.gov/pubmed/16917073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0230OC |
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