An afferent vagal nerve pathway links hepatic PPARα activation to glucocorticoid-induced insulin resistance and hypertension

Glucocorticoid excess causes insulin resistance and hypertension. Hepatic expression of PPARα (Ppara) is required for glucocorticoid-induced insulin resistance. Here we demonstrate that afferent fibers of the vagus nerve interface with hepatic Ppara expression to disrupt blood pressure and glucose h...

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Main Authors: Bernal-Mizrachi, Carlos, Xiaozhong, Liu, Yin, Li, Knutsen, Russell H., Howard, Michael J., Arends, Joop J. A., DeSantis, Pascual, Coleman, Trey, Semenkovich, Clay F.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899170/
https://ncbi.nlm.nih.gov/pubmed/17276352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2006.12.010
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