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Proteolytic Degradation of SCOP in the Hippocampus Contributes to Activation of MAP Kinase and Memory

Because activation of Erk1/2 MAP kinase (MAPK) is critical for hippocampus-dependent memory, there is considerable interest in mechanisms for regulation of MAPK during memory formation. Here we report that MAPK and CREB-mediated transcription are negatively regulated by SCOP (SCN Circadian Oscillato...

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Autors principals: Shimizu, Kimiko, Phan, Trongha, Mansuy, Isabelle, Storm, Daniel R.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899088/
https://ncbi.nlm.nih.gov/pubmed/17382888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.047
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