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An aspartic acid at amino acid 108 is required to rescue infectious virus after transfection of a poliovirus cDNA containing a CGDD but not SGDD amino acid motif in 3Dpol.

The poliovirus RNA-dependent RNA polymerase (3Dpol) contains a region of homology centered around the amino acid motif YGDD (amino acids 326 to 329), which has been postulated to be involved in the catalytic activity of the enzyme. Previous studies from this laboratory have used oligonucleotide site...

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Published in:J Virol
Main Authors: Walker, D E, McPherson, D, Jablonski, S A, McPherson, S, Morrow, C D
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189777/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7494345/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.12.8173-8177.1995
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