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A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells.

Poxviruses are unique among viruses in encoding members of the serine proteinase inhibitor (serpin) superfamily. Orthopoxviruses contain three serpins, designated SPI-1, SPI-2, and SPI-3. SPI-1 encodes a 40-kDa protein that is required for the replication of rabbitpox virus (RPV) in PK-15 or A549 ce...

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Bibliographic Details
Published in:J Virol
Main Authors: Brooks, M A, Ali, A N, Turner, P C, Moyer, R W
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1995
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189710/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7494278/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.12.7688-7698.1995
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