Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.

Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disease of humans caused by an unidentified infectious agent, the prion. To determine whether there was an involvement of the host-encoded prion protein (PrPc) in CJD development and prion propagation, mice heterozygous (PrP+/-) or...

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Autores principales: Sakaguchi, S, Katamine, S, Shigematsu, K, Nakatani, A, Moriuchi, R, Nishida, N, Kurokawa, K, Nakaoke, R, Sato, H, Jishage, K
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC189697/
https://ncbi.nlm.nih.gov/pubmed/7494265
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