An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity.

Infectious retrovirus particles are derived from structural polyproteins which are cleaved by the viral proteinase (PR) during virion morphogenesis. Besides cleaving viral polyproteins, which is essential for infectivity, PR of human immunodeficiency virus (HIV) also cleaves cellular proteins and PR...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Konvalinka, J, Litterst, M A, Welker, R, Kottler, H, Rippmann, F, Heuser, A M, Kräusslich, H G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7474139/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.11.7180-7186.1995
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