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Catalytic mechanism of Zn(2+)-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu(154)→Cys forms of yeast xylitol dehydrogenase

Co-ordination of catalytic Zn(2+) in sorbitol/xylitol dehydrogenases of the medium-chain dehydrogenase/reductase superfamily involves direct or water-mediated interactions from a glutamic acid residue, which substitutes a homologous cysteine ligand in alcohol dehydrogenases of the yeast and liver ty...

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Detalles Bibliográficos
Main Authors: Klimacek, Mario, Hellmer, Heidemarie, Nidetzky, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896283/
https://ncbi.nlm.nih.gov/pubmed/17343568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061384
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