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Changing T cell specificity by retroviral T cell receptor display

The diversity of the T cell receptor (TCR) repertoire is limited, because of the processes of positive and negative T cell selection. To obtain T cells with specificities beyond the immune system's capacity, we have developed a strategy for retroviral TCR display. In this approach, a library of...

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Detalhes bibliográficos
Main Authors: Kessels, Helmut W. H. G., van den Boom, Marly D., Spits, Hergen, Hooijberg, Erik, Schumacher, Ton N. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18961/
https://ncbi.nlm.nih.gov/pubmed/11121060
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