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Changing T cell specificity by retroviral T cell receptor display

The diversity of the T cell receptor (TCR) repertoire is limited, because of the processes of positive and negative T cell selection. To obtain T cells with specificities beyond the immune system's capacity, we have developed a strategy for retroviral TCR display. In this approach, a library of T ce...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kessels, Helmut W. H. G., van den Boom, Marly D., Spits, Hergen, Hooijberg, Erik, Schumacher, Ton N. M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18961/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11121060/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.26.14578
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