Directed evolution of gene-shuffled IFN-α molecules with activity profiles tailored for treatment of chronic viral diseases

Type I IFNs are unusually pleiotropic cytokines that bind to a single heterodimeric receptor and have potent antiviral, antiproliferative, and immune modulatory activities. The diverse effects of the type I IFNs are of differential therapeutic importance; in cancer therapy, an enhanced antiprolifera...

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Detalhes bibliográficos
Main Authors: Brideau-Andersen, Amy D., Huang, Xiaojian, Sun, Siu-Chi Chang, Chen, Teddy T., Stark, Diane, Sas, Ian J., Zadik, Linda, Dawes, Glenn N., Guptill, Douglas R., McCord, Robert, Govindarajan, Sridhar, Roy, Ajoy, Yang, Shumin, Gao, Judy, Chen, Yong Hong, Skartved, Niels Jørgen Ø., Pedersen, Annette K., Lin, David, Locher, Christopher P., Rebbapragada, Indrani, Jensen, Anne Dam, Bass, Steven H., Nissen, Torben L. Straight, Viswanathan, Sridhar, Foster, Graham R., Symons, Julian A., Patten, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895939/
https://ncbi.nlm.nih.gov/pubmed/17494769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609001104
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