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THE CRYSTAL STRUCTURE OF IRON-FREE HUMAN SERUM TRANSFERRIN PROVIDES INSIGHT INTO INTER-LOBE COMMUNICATION AND RECEPTOR BINDING
Serum transferrin reversibly binds iron in each of two lobes and delivers it to cells by a receptor-mediated, pH-dependant process. The binding and release of iron results in a large conformational change in which two subdomains in each lobe close or open with a rigid twisting motion around a hinge....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895924/ https://ncbi.nlm.nih.gov/pubmed/16793765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M604592200 |
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