Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence

The antiviral thymidine analog azidothymidine (AZT) is used to treat several virus-associated human cancers. However, to date the mechanism of AZT action remains unclear and thus, reasons for treatment failure are unknown. Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of poor prog...

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Autori principali: Datta, Abhik, Bellon, Marcia, Sinha-Datta, Uma, Bazarbachi, Ali, Lepelletier, Yves, Canioni, Danielle, Waldmann, Thomas A., Hermine, Olivier, Nicot, Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895862/
https://ncbi.nlm.nih.gov/pubmed/16569765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-0067
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