Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells

Mast cells are responsible for IgE-mediated allergic reactions. Phospholipase D1 (PLD1) and PLD2 regulate mast cell activation, but the mechanisms remain unclear. Here we show that PLD2 associates with and promotes activation of Syk, a key enzyme in mast cell activation. Antigen stimulation resulted...

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Detalhes bibliográficos
Main Authors: Lee, Jun Ho, Kim, Young Mi, Kim, Nam Wook, Kim, Jie Wan, Her, Erk, Kim, Bo Kyung, Kim, Jong Hyun, Ryu, Sung Ho, Park, Jong Woo, Seo, Dong Wan, Han, Jeung Whan, Beaven, Michael A., Choi, Wahn Soo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895856/
https://ncbi.nlm.nih.gov/pubmed/16861349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-10-009159
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