Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells

Mast cells are responsible for IgE-mediated allergic reactions. Phospholipase D1 (PLD1) and PLD2 regulate mast cell activation, but the mechanisms remain unclear. Here we show that PLD2 associates with and promotes activation of Syk, a key enzyme in mast cell activation. Antigen stimulation resulted...

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Détails bibliographiques
Auteurs principaux: Lee, Jun Ho, Kim, Young Mi, Kim, Nam Wook, Kim, Jie Wan, Her, Erk, Kim, Bo Kyung, Kim, Jong Hyun, Ryu, Sung Ho, Park, Jong Woo, Seo, Dong Wan, Han, Jeung Whan, Beaven, Michael A., Choi, Wahn Soo
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2006
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895856/
https://ncbi.nlm.nih.gov/pubmed/16861349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-10-009159
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