ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

Tightly regulated expression of the transcription factor PU.1 is crucial for normal hematopoiesis. PU.1 knockdown mice develop acute myeloid leukemia (AML), and PU.1 mutations have been observed in some populations of patients with AML. Here we found that conditional expression of promyelocytic leuk...

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Detalhes bibliográficos
Main Authors: Mueller, Beatrice U., Pabst, Thomas, Fos, José, Petkovic, Vibor, Fey, Martin F., Asou, Norio, Buergi, Ulrich, Tenen, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895760/
https://ncbi.nlm.nih.gov/pubmed/16352814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-3068
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