The structure of the GPIb–filamin A complex

Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the platelet adhesion glycoprotein (GP) Ib-IX-V receptor to actin cytoskeleton. We mapped the GPIbα binding site to a single domain of FLNa and resolved the structure of this do...

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Autors principals: Nakamura, Fumihiko, Pudas, Regina, Heikkinen, Outi, Permi, Perttu, Kilpeläinen, Ilkka, Munday, Adam D., Hartwig, John H., Stossel, Thomas P., Ylänne, Jari
Format: Artigo
Idioma:Inglês
Publicat: © 2006 by The American Society of Hematology 2006
Matèries:
Hemostasis, Thrombosis, and Vascular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895705/
https://ncbi.nlm.nih.gov/pubmed/16293600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-10-3964
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