Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

BACKGROUND: Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans. METHODOLOGY/PRINCIPAL FINDINGS: We determined the structure of the 23(rd) Ig repeat of FLNa (IgFLNa23) that interacts with FilGAP, a Rac-specific GTPa...

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Hauptverfasser: Nakamura, Fumihiko, Heikkinen, Outi, Pentikäinen, Olli T., Osborn, Teresia M., Kasza, Karen E., Weitz, David A., Kupiainen, Olga, Permi, Perttu, Kilpeläinen, Ilkka, Ylänne, Jari, Hartwig, John H., Stossel, Thomas P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654154/
https://ncbi.nlm.nih.gov/pubmed/19293932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004928
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