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Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations
BACKGROUND: Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans. METHODOLOGY/PRINCIPAL FINDINGS: We determined the structure of the 23(rd) Ig repeat of FLNa (IgFLNa23) that interacts with FilGAP, a Rac-specific GTPa...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654154/ https://ncbi.nlm.nih.gov/pubmed/19293932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004928 |
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