Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis

Granulocyte colony-stimulating factor (G-CSF) is the principal cytokine regulating granulopoiesis. Truncation mutations of the G-CSF receptor (G-CSFR) are associated with the development of acute myeloid leukemia in patients with severe congenital neutropenia. Although increased proliferative signal...

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Autori principali: Mermel, Craig H., McLemore, Morgan L., Liu, Fulu, Pereira, Shalini, Woloszynek, Jill, Lowell, Clifford A., Link, Daniel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2006 by The American Society of Hematology 2006
Soggetti:
Hematopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895577/
https://ncbi.nlm.nih.gov/pubmed/16772601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-024307
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