FcγR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

Phagocytosis of IgG-coated particles via FcγR is accompanied by the generation of superoxide and inflammatory cytokines, which can cause collateral tissue damage in the absence of regulation. Molecular mechanisms regulating these phagocytosis-associated events are not known. SHIP is an inositol phos...

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Autori principali: Ganesan, Latha P., Joshi, Trupti, Fang, Huiqing, Kutala, Vijay Kumar, Roda, Julie, Trotta, Rossana, Lehman, Amy, Kuppusamy, Periannan, Byrd, John C., Carson, William E., Caligiuri, Michael A., Tridandapani, Susheela
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Phagocytes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895481/
https://ncbi.nlm.nih.gov/pubmed/16543474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3889
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