Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal

Oxaliplatin and fludarabine have different but potentially complementary mechanisms of action. Previous studies have shown that DNA repair is a major target for fludarabine. We postulate that potentiation of oxaliplatin toxicity by fludarabine may be due to the inhibition by fludarabine of the activ...

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Autors principals: Moufarij, Mazin A., Sampath, Deepa, Keating, Michael J., Plunkett, William
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895455/
https://ncbi.nlm.nih.gov/pubmed/16954499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-023259
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