Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia

We conducted a phase 1/2 study of the combination of 5-aza-2′-deoxycytidine (decitabine) and the histone deacetylase inhibitor valproic acid (VPA) in patients with advanced leukemia, including older untreated patients. A group of 54 patients were treated with a fixed dose of decitabine (15 mg/m(2) b...

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Bibliographic Details
Main Authors: Garcia-Manero, Guillermo, Kantarjian, Hagop M., Sanchez-Gonzalez, Blanca, Yang, Hui, Rosner, Gary, Verstovsek, Srdan, Rytting, Michael, Wierda, William G., Ravandi, Farhad, Koller, Charles, Xiao, Lianchun, Faderl, Stefan, Estrov, Zeev, Cortes, Jorge, O'Brien, Susan, Estey, Elihu, Bueso-Ramos, Carlos, Fiorentino, Jackie, Jabbour, Elias, Issa, Jean-Pierre
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Clinical Trials and Observations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895437/
https://ncbi.nlm.nih.gov/pubmed/16882711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-009142
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