Genetic reduction of class I(A) PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Class I(A) phosphatidylinositol-3 kinase (PI-3K) is a lipid kinase, which is activated in blood cells by hematopoietic growth factors. In vitro experiments using chemical inhibitors of PI-3K suggest that this kinase is potentially important for hematopoietic stem and progenitor cell (HSC/P) function...

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Bibliographische Detailangaben
Hauptverfasser: Haneline, Laura S., White, Hilary, Yang, Feng-Chun, Chen, Shi, Orschell, Christie, Kapur, Reuben, Ingram, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2006 by The American Society of Hematology 2006
Schlagworte:
Hematopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895408/
https://ncbi.nlm.nih.gov/pubmed/16239435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1985
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