Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells

Hypoxia is a major pathophysiological condition for the induction of angiogenesis, which is a crucial aspect of growth in solid tumors. In mammalian cells, the transcriptional response to oxygen deprivation is largely mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer composed of HIF-1α a...

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Bibliografiska uppgifter
Huvudupphovsmän: Calvani, Maura, Rapisarda, Annamaria, Uranchimeg, Badarch, Shoemaker, Robert H., Melillo, Giovanni
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society of Hematology 2006
Ämnen:
Hemostasis, Thrombosis, and Vascular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895390/
https://ncbi.nlm.nih.gov/pubmed/16304044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3541
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