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Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells
IL-11 and its receptor, IL-11Ra, are expressed in human cancers; however, the functional role of IL-11 in tumor progression is not known. We found that IL11 is a hypoxia-inducible, VHL-regulated gene in human cancer cells and that expression of IL11 mRNA was dependent, at least in part, on HIF-1. A...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613900/ https://ncbi.nlm.nih.gov/pubmed/23549086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59623 |
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