FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis

We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and potentiates stimulation of endothelial-cell (EC) proliferation. We have now used 2 FGF-2 mutants differing only in the 5 residues constituting the binding site to characterize the importance of this interaction i...

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Autori principali: Sahni, Abha, Khorana, Alok A., Baggs, Raymond B., Peng, Hu, Francis, Charles W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2006 by The American Society of Hematology 2006
Soggetti:
Hemostasis, Thrombosis, and Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895359/
https://ncbi.nlm.nih.gov/pubmed/16160009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2460
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