Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti–CTLA-4 antibodies

Although results from preclinical studies in animal models have proven the concept for use of anti–cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibodies in cancer immunotherapy, 2 major obstacles have hindered their successful application for human cancer therapy. First, the lack of in vitro correlat...

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Detalhes bibliográficos
Main Authors: Lute, Kenneth D., May, Kenneth F., Lu, Ping, Zhang, Huiming, Kocak, Ergun, Mosinger, Bedrick, Wolford, Christopher, Phillips, Gary, Caligiuri, Michael A., Zheng, Pan, Liu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895337/
https://ncbi.nlm.nih.gov/pubmed/16037385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2298
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