Critical role for CCR5 in the function of donor CD4(+)CD25(+) regulatory T cells during acute graft-versus-host disease

CD4(+)CD25(+) regulatory T cells (T(regs)) have been shown to inhibit graft-versus-host disease (GVHD) in murine models, and this suppression was mediated by T(regs) expressing the lymphoid homing molecule l-selectin. Here, we demonstrate that T(regs) lacking expression of the chemokine receptor CCR...

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Bibliographic Details
Main Authors: Wysocki, Christian A., Jiang, Qi, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., McKinnon, Karen P., Su, Lishan, Blazar, Bruce R., Serody, Jonathan S.
Format: Artigo
Language:Inglês
Published: © 2005 by The American Society of Hematology 2005
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895335/
https://ncbi.nlm.nih.gov/pubmed/16002422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1632
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