CD4(+)CD25(+) regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy

CD4(+)CD25(+) regulatory T cells (Tregs) are essential negative regulators of immune responses. Here, we examined the signaling properties of human Tregs, using CD4(+)CD25(+) Treg and CD4(+)CD25(–) control (Tcont) cell lines generated from cord blood. Treg cell lines were markedly hyporesponsive to...

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Bibliografiske detaljer
Main Authors: Li, Lequn, Godfrey, Wayne R., Porter, Stephen B., Ge, Ying, June, Carle H., Blazar, Bruce R., Boussiotis, Vassiliki A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2005
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895332/
https://ncbi.nlm.nih.gov/pubmed/16020508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1531
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