The hydroxyurea-induced small GTP-binding protein SAR modulates γ-globin gene expression in human erythroid cells

Hydroxyurea (HU), a drug effective in the treatment of sickle cell disease, is thought to indirectly promote fetal hemoglobin (Hb F) production by perturbing the maturation of erythroid precursors. The molecular mechanisms involved in HU-mediated regulation of γ-globin expression are currently uncle...

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Hlavní autoři: Tang, Delia C., Zhu, Jianqiong, Liu, Wenli, Chin, Kyung, Sun, Jun, Chen, Ling, Hanover, John A., Rodgers, Griffin P.
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2005 by The American Society of Hematology 2005
Témata:
Red Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895330/
https://ncbi.nlm.nih.gov/pubmed/15985540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2003-10-3458
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