Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

We report, for the first time, a replication-defective retroviral vector–associated neoplasia in a nonhuman primate. Five years after transplantation with CD34(+) cells transduced with a retroviral vector expressing enhanced green fluorescent protein (eGFP) and a drug-resistant variant of the dihydr...

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Autori principali: Seggewiss, Ruth, Pittaluga, Stefania, Adler, Rima L., Guenaga, F. Javier, Ferguson, Cole, Pilz, Ingo H., Ryu, Byoung, Sorrentino, Brian P., Young, W. Scott, Donahue, Robert E., von Kalle, Christof, Nienhuis, Arthur W., Dunbar, Cynthia E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895280/
https://ncbi.nlm.nih.gov/pubmed/16439674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-10-4108
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