Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

Recent reports linking insertional activation of LMO2 following gene therapy for X-linked severe combined immunodeficiency (X-SCID) have led to a re-evaluation of risks following gene therapy with retroviral vectors. In our analysis of 702 integration sites in rhesus macaques that underwent transpla...

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Autors principals: Calmels, Boris, Ferguson, Cole, Laukkanen, Mikko O., Adler, Rima, Faulhaber, Marion, Kim, Hyeoung-Joon, Sellers, Stephanie, Hematti, Peiman, Schmidt, Manfred, von Kalle, Christof, Akagi, Keiko, Donahue, Robert E., Dunbar, Cynthia E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895268/
https://ncbi.nlm.nih.gov/pubmed/15933056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1115
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