Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

Leukemic blasts from patients with acute myeloid leukemia (AML) frequently express high levels of the interleukin-3 receptor α chain (IL-3Rα). In the present study, we have explored the sensitivity of primary leukemic blasts obtained from 34 patients with AML to a diphtheria toxin (DT) composed of t...

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Main Authors: Testa, Ugo, Riccioni, Roberta, Biffoni, Mauro, Diverio, Daniela, Lo-Coco, Francesco, Foà, Robin, Peschle, Cesare, Frankel, Arthur E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2005
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895267/
https://ncbi.nlm.nih.gov/pubmed/15928038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0540
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