A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme could serve as a therapeutic target. Inhibitors of PNP failed until structure-based synthesis of immucillin-H (BCX-1777, forodesine), a transition-state analog of PNP. The...

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Main Authors: Gandhi, Varsha, Kilpatrick, John M., Plunkett, William, Ayres, Mary, Harman, Leigh, Du, Min, Bantia, Shanta, Davisson, Jan, Wierda, William G., Faderl, Stefan, Kantarjian, Hagop, Thomas, Deborah
Format: Artigo
Jezik:Inglês
Izdano: © 2005 by The American Society of Hematology 2005
Teme:
Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895256/
https://ncbi.nlm.nih.gov/pubmed/16131572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1309
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