Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer

Hemophilia A is a clinically important coagulation disorder caused by the lack or abnormality of plasma coagulation factor VIII (FVIII). Gene transfer of the FVIII cDNA to hepatocytes using lentiviral vectors is a potential therapeutic approach. We investigated the efficacy of feline immunodeficienc...

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Main Authors: Kang, Yubin, Xie, Litao, Tran, Diane Thi, Stein, Colleen S., Hickey, Melissa, Davidson, Beverly L., McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society of Hematology 2005
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895217/
https://ncbi.nlm.nih.gov/pubmed/15886327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4358
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