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Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice
Although c-Maf is crucial for Th2 differentiation and production of interleukin 4 (IL-4), its regulation is poorly understood. We report that Vav1(–/–) CD4(+) T cells display deficient T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, enhanced interferon γ (IFN-γ) product...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895205/ https://ncbi.nlm.nih.gov/pubmed/15845902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4074 |
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