Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis

It has been shown that mice with complete deficiency of all 4.1R protein isoforms (4.1(-/-)) exhibit moderate hemolytic anemia, with abnormal erythrocyte morphology (spherocytosis) and decreased membrane stability. Here, we characterized the Gardos channel function in vitro and in vivo in erythrocyt...

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Autores principales: De Franceschi, Lucia, Rivera, Alicia, Fleming, Mark D., Honczarenko, Marek, Peters, Luanne L., Gascard, Philippe, Mohandas, Narla, Brugnara, Carlo
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2005
Materias:
Red Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895196/
https://ncbi.nlm.nih.gov/pubmed/15855279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0368
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