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The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

Melphalan, a DNA cross-linker, is one of the most widely used and effective drugs in the treatment of multiple myeloma (MM). In this report, we demonstrate that enhanced interstrand cross-link (ICL) repair via the Fanconi anemia (FA)/BRCA pathway contributes to acquired drug resistance in melphalan-...

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Detalhes bibliográficos
Main Authors: Chen, Qing, Van der Sluis, Pieter C., Boulware, David, Hazlehurst, Lori A., Dalton, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895179/
https://ncbi.nlm.nih.gov/pubmed/15802532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4286
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