Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

Viral heterogeneity is a major hurdle for potential therapeutic use of RNA interference (RNAi) against HIV-1. To determine the extent of RNAi tolerance to mutations, we tested 3 viral target sites with differing propensity for mutations: a highly variable rev sequence, a gag sequence conserved only...

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Autori principali: Lee, Sang-Kyung, Dykxhoorn, Derek M., Kumar, Priti, Ranjbar, Shahin, Song, Erwei, Maliszewski, Laura E., François-Bongarçon, Vanessa, Goldfeld, Anne, Swamy, N. Manjunath, Lieberman, Judy, Shankar, Premlata
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2005
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895148/
https://ncbi.nlm.nih.gov/pubmed/15831707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-3959
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