Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages

Small interfering RNAs (siRNAs) can induce potent gene silencing by degradation of cognate mRNA. However, in dividing cells, the silencing lasts only 3 to 7 days, presumably because of siRNA dilution with cell division. Here, we investigated if sustained siRNA-mediated silencing of human immunodefic...

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Detalhes bibliográficos
Main Authors: Song, Erwei, Lee, Sang-Kyung, Dykxhoorn, Derek M., Novina, Carl, Zhang, Dong, Crawford, Keith, Cerny, Jan, Sharp, Phillip A., Lieberman, Judy, Manjunath, N, Shankar, Premlata
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164789/
https://ncbi.nlm.nih.gov/pubmed/12805416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.13.7174-7181.2003
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