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Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation
The mechanism by which arsenic dramatically affects gene expression remains poorly understood. Here we report that prolonged exposure of acute promyelocytic leukemia NB4 cells to low levels of arsenic trioxide increased the expression of a set of genes responsible for reactive oxygen species (ROS) p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
© 2005 by The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895131/ https://ncbi.nlm.nih.gov/pubmed/15761015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0241 |
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