Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation

Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In thi...

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Autors principals: Kanaji, Sachiko, Kanaji, Taisuke, Jacquelin, Beatrice, Chang, Mei, Nugent, Diane J., Komatsu, Norio, Moroi, Masaaki, Izuhara, Kenji, Kunicki, Thomas J.
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Hemostasis, Thrombosis, and Vascular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895081/
https://ncbi.nlm.nih.gov/pubmed/15701720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3109
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