Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation

Glycoprotein VI (GPVI) is an essential platelet receptor for collagens that is exclusively expressed in the megakaryocytic lineage. Transcription of the human gene GP6 is driven largely by GATA-binding protein 1 (GATA-1), specificity protein 1 (Sp1), and Friend leukemia integration 1 (Fli-1). In thi...

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Autores principales: Kanaji, Sachiko, Kanaji, Taisuke, Jacquelin, Beatrice, Chang, Mei, Nugent, Diane J., Komatsu, Norio, Moroi, Masaaki, Izuhara, Kenji, Kunicki, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2005 by The American Society of Hematology 2005
Materias:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895081/
https://ncbi.nlm.nih.gov/pubmed/15701720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3109
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