The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies. Recently, we and others identified a single recurrent somatic activating mutation (JAK2V617F) in the Janus kinase 2 (JAK2) tyrosine kinase in the myeloproliferative disorders (MPDs) poly...

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Detalhes bibliográficos
Main Authors: Levine, Ross L., Loriaux, Marc, Huntly, Brian J. P., Loh, Mignon L., Beran, Miroslav, Stoffregen, Eric, Berger, Roland, Clark, Jennifer J., Willis, Stephanie G., Nguyen, Kim T., Flores, Nikki J., Estey, Elihu, Gattermann, Norbert, Armstrong, Scott, Look, A. Thomas, Griffin, James D., Bernard, Olivier A., Heinrich, Michael C., Gilliland, D. Gary, Druker, Brian, Deininger, Michael W. N.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895066/
https://ncbi.nlm.nih.gov/pubmed/16081687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1898
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