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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
The Akt kinases promote hematopoietic cell growth and accumulation through phosphorylation of apoptotic effectors and stimulation of mTOR-dependent translation. In Akt-transformed leukemic cells, tumor growth can be inhibited by the mTOR inhibitor rapamycin, and clinical trials of rapamycin analogs...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
© 2005 by The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895036/ https://ncbi.nlm.nih.gov/pubmed/15705789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-09-3706 |
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