The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing.

Eitemau Tebyg

• The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0.
  gan: Sekulovich, R E, et al.
  Cyhoeddwyd: (1988)
• Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect.
  gan: Hardy, W R, et al.
  Cyhoeddwyd: (1994)
• The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection.
  gan: Hardwicke, M A, et al.
  Cyhoeddwyd: (1994)
• The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.
  gan: Hardwicke, M A, et al.
  Cyhoeddwyd: (1989)
• The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction.
  gan: Sandri-Goldin, R M, et al.
  Cyhoeddwyd: (1996)