Transglutaminase-mediated oligomerization of the fibrin(ogen) αC domains promotes integrin-dependent cell adhesion and signaling

Interactions of endothelial cells with fibrin(ogen) are implicated in inflammation, angiogenesis, and wound healing. Cross-linking of the fibrinogen αC domains with factor XIIIa generates ordered αC oligomers mimicking polymeric arrangement of the αC domains in fibrin. These oligomers and those prep...

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Autori principali: Belkin, Alexey M., Tsurupa, Galina, Zemskov, Evgeny, Veklich, Yuri, Weisel, John W., Medved, Leonid
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2005 by The American Society of Hematology 2005
Soggetti:
Hemostasis, Thrombosis, and Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895018/
https://ncbi.nlm.nih.gov/pubmed/15637140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-10-4089
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