Activation of Th1 and Tc1 cell adenosine A(2A) receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo

To evaluate the direct effect of adenosine on cytokine-polarized effector T cells, murine type 1 helper T cells (Th1) and type 1 cytotoxic T lymphocytes (Tc1) and Th2/Tc2 cells were generated using an antigen-presenting cell (APC)-free method. Tc1 and Tc2 cells had similar adenosine signaling, as me...

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Detalhes bibliográficos
Main Authors: Erdmann, Andreas A., Gao, Zhan-Guo, Jung, Unsu, Foley, Jason, Borenstein, Todd, Jacobson, Kenneth A., Fowler, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895001/
https://ncbi.nlm.nih.gov/pubmed/15746085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-04-1407
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