HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

The HIV-1 central DNA Flap acts as a cis-acting determinant of HIV-1 genome nuclear import. Indeed, DNA-Flap re-insertion within lentiviral-derived gene transfer vectors strongly stimulates gene transfer efficiencies. In this study, we sought to understand the mechanisms by which the central DNA Fla...

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Autores principales: Arhel, Nathalie J, Souquere-Besse, Sylvie, Munier, Sandie, Souque, Philippe, Guadagnini, Stéphanie, Rutherford, Sandra, Prévost, Marie-Christine, Allen, Terry D, Charneau, Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894778/
https://ncbi.nlm.nih.gov/pubmed/17557080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601740
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