Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug

AIM: To examine the suspected inhibitory potential of the over-the-counter (OTC) drug ibuprofen on N-acetyltransferase 2 (NAT2) in vitro and in vivo and the possible implications for phenotyping procedures using caffeine as probe drug. METHODS: We first studied the inhibitory effect of ibuprofen on...

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Bibliografiske detaljer
Main Authors: Vrtic, Fatima, Haefeli, Walter E, Drewe, Jürgen, Krähenbühl, Stephan, Wenk, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2003
Fag:
Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894741/
https://ncbi.nlm.nih.gov/pubmed/12580991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01725.x
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